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The vulnerability of CSCs to treatment with inhibitors of OXPHOS has been illustrated in different studies, so far the repression of self-renewal and stemness properties and substantial temporary tumor growth/formation was observed during treatment with metformin as an inhibitor of the OXPHOS complex I [103, 123,124,125]
Nuclear factor erythroid 2-related factor 2 (Nrf2) is instrumental in mitigating neuronal oxidative stress and glutamate-induced excitotoxicity
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Ingredients: Berberine, Fenugreek Seed (Trigonella foenum-graecum), Astragalus Root (Astragalus membranaceus), Banaba Leaf Extract (Lagerstroemia speciosa), Cinnamon extract (Cinnamomum cassia), Peppermint Leaf (Mentha x Piperita) and Natural Trace Minerals